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Glycophorin B carries the blood group antigens N, Ss and U. Both glycophorin A and B bind the ''[[Vicia graminea]]'' anti-N lectin. S and s antigens are not affected by treatment with [[trypsin]] or [[sialidase]] but are destroyed or much depressed by treatment with [[papain]], [[pronase]] or [[alpha-chymotrypsin]].
The M and N antigens differ at two amino acid residues: the M allele has serine at position 1 (C at nucleotide 2) and glycine at position 5 (G at nucleotide 14) while the N allele has leucine at position 1 (T at nucleotide 2) and glutamate at position 5 (A at nucleotide 14).
Individuals who lack GypB have the phenotype S-s-U-. This may occur at frequencies of 20% in some African pygmies.
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